KPV vs MOTS-C
KPV and MOTS-C come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
at a glance
what each one is
KPV
Tripeptide alpha-MSH fragment
KPV is a tripeptide composed of lysine, valine, and proline, corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It is the smallest sequence retained from that parent peptide and is widely used as a compact reference compound in cellular signaling research, where its short chain length makes it convenient for controlled in-vitro work.
full KPV profile →MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →where the research differs
Both compounds are supplied strictly for laboratory research use only. Reported research contexts for each:
KPV
- Inflammatory-signaling research models (NF-κB pathway studies)
- Cytokine-expression research in cultured cells
- Melanocortin-receptor and alpha-MSH fragment research
- Epithelial and mucosal-barrier research models
- Structure–activity studies of short peptide fragments
MOTS-C
- Mitochondrial-derived peptide and retrograde-signaling research
- AMPK pathway research models
- One-carbon (folate–methionine) metabolism studies
- Cellular energy-metabolism and substrate-utilization research
- Exercise-physiology and metabolic-stress research models
shop either compound
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
build a stack with both →frequently asked
What is KPV?
KPV is a tripeptide (lysine-valine-proline) corresponding to the C-terminal fragment of alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is KPV studied for in research?
In in-vitro and pre-clinical models it is used as a reference compound in inflammatory-signaling, cytokine-expression, and melanocortin-pathway research. Verve makes no claims about use in humans or animals.
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.