5-Amino-1MQ vs MOTS-C
5-Amino-1MQ and MOTS-C are both studied in weight research, but they are different classes of compound with different reported research applications.
✓ both US-made · third-party tested · batch COA on every order
at a glance
what each one is
5-Amino-1MQ
Small-molecule enzyme inhibitor (not a peptide)
5-Amino-1MQ is a small molecule rather than a peptide: a methylquinolinium compound that acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT). It is cell-permeable and carries a permanent positive charge on its quaternary nitrogen, a structural feature that shapes how it distributes in cellular assays and why it is used as a tool compound in enzyme-inhibition research.
full 5-Amino-1MQ profile →MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →where the research differs
Both compounds are supplied strictly for laboratory research use only. Reported research contexts for each:
5-Amino-1MQ
- NNMT enzyme-inhibition and kinetics research
- NAD+ salvage-pathway and nicotinamide-metabolism studies
- S-adenosylmethionine and methyl-donor balance research
- Adipocyte and cellular energy-metabolism research models
- Small-molecule structure–activity and selectivity studies
MOTS-C
- Mitochondrial-derived peptide and retrograde-signaling research
- AMPK pathway research models
- One-carbon (folate–methionine) metabolism studies
- Cellular energy-metabolism and substrate-utilization research
- Exercise-physiology and metabolic-stress research models
shop either compound
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
build a stack with both →frequently asked
What is 5-Amino-1MQ?
5-Amino-1MQ is a small molecule, not a peptide — a methylquinolinium compound that selectively inhibits the enzyme nicotinamide N-methyltransferase (NNMT). Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
Is 5-Amino-1MQ a peptide?
No. It is a small-molecule enzyme inhibitor with no amino-acid backbone, which is why it is handled and stored differently from the peptides in the catalog. It is supplied strictly for laboratory research.
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.