MOTS-C vs NAD+
MOTS-C and NAD+ come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
at a glance
what each one is
MOTS-C
Mitochondrial-derived 16-amino-acid peptide
MOTS-c is a 16-amino-acid peptide encoded not by nuclear DNA but by a short open reading frame within the mitochondrial 12S rRNA gene. It belongs to the mitochondrial-derived peptide family, a group of small peptides that are of interest in research precisely because their genetic origin sits inside the organelle rather than the nucleus.
full MOTS-C profile →NAD+
Nicotinamide adenine dinucleotide · cellular-metabolism research
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every living cell and central to redox reactions and cellular energy metabolism. Verve's NAD+ is a high-purity research preparation supplied for the laboratory study of cellular energetics and redox biology.
full NAD+ profile →where the research differs
Both compounds are supplied strictly for laboratory research use only. Reported research contexts for each:
MOTS-C
- Mitochondrial-derived peptide and retrograde-signaling research
- AMPK pathway research models
- One-carbon (folate–methionine) metabolism studies
- Cellular energy-metabolism and substrate-utilization research
- Exercise-physiology and metabolic-stress research models
NAD+
- Cellular energy-metabolism research
- Sirtuin and PARP enzyme research
- Mitochondrial-function research models
- Redox-biology (NAD+/NADH ratio) research
- Longevity and cellular-aging research models
shop either compound
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
build a stack with both →frequently asked
What is MOTS-C?
MOTS-c is a 16-amino-acid peptide encoded by a short open reading frame in the mitochondrial genome. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is MOTS-C studied for in research?
It is used in mitochondrial-signaling research, including AMPK pathway activity, one-carbon metabolism, and retrograde signaling between mitochondria and the nucleus in in-vitro and pre-clinical models. Verve makes no health claims.
What is NAD+?
NAD+ is nicotinamide adenine dinucleotide, a coenzyme central to redox reactions and energy metabolism in cells. Verve supplies a high-purity research preparation for laboratory use only.
What is NAD+ studied for in research?
It is used in research on cellular energy metabolism, sirtuin and PARP enzyme activity, mitochondrial function, and DNA-repair pathways. It is not for human or veterinary use.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.