IGF-1 LR3 vs KPV
IGF-1 LR3 and KPV come from different research areas and are studied in largely separate models — researchers usually compare them when scoping a broader protocol.
✓ both US-made · third-party tested · batch COA on every order
at a glance
what each one is
IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →KPV
Tripeptide alpha-MSH fragment
KPV is a tripeptide composed of lysine, valine, and proline, corresponding to the C-terminal fragment (residues 11–13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It is the smallest sequence retained from that parent peptide and is widely used as a compact reference compound in cellular signaling research, where its short chain length makes it convenient for controlled in-vitro work.
full KPV profile →where the research differs
Both compounds are supplied strictly for laboratory research use only. Reported research contexts for each:
IGF-1 LR3
- IGF-1 receptor binding and signal-transduction research
- PI3K/Akt and MAPK pathway research in cellular models
- Cell-culture media supplementation for proliferation research
- IGFBP interaction and free-ligand availability studies
- Comparative analog research against native IGF-1
KPV
- Inflammatory-signaling research models (NF-κB pathway studies)
- Cytokine-expression research in cultured cells
- Melanocortin-receptor and alpha-MSH fragment research
- Epithelial and mucosal-barrier research models
- Structure–activity studies of short peptide fragments
shop either compound
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
build a stack with both →frequently asked
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
What is KPV?
KPV is a tripeptide (lysine-valine-proline) corresponding to the C-terminal fragment of alpha-MSH. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is KPV studied for in research?
In in-vitro and pre-clinical models it is used as a reference compound in inflammatory-signaling, cytokine-expression, and melanocortin-pathway research. Verve makes no claims about use in humans or animals.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.