CJC-1295 / Ipamorelin vs IGF-1 LR3
CJC-1295 / Ipamorelin and IGF-1 LR3 are both studied in longevity research, but they are different classes of compound with different reported research applications.
✓ both US-made · third-party tested · batch COA on every order
at a glance
what each one is
CJC-1295 / Ipamorelin
Co-formulated GHRH-analog and secretagogue blend
CJC-1295 / Ipamorelin is a co-formulated research blend of two peptides that act at separate receptors. CJC-1295 without DAC, also referred to as Mod GRF 1-29, is a modified 29-amino-acid analog of growth-hormone-releasing hormone characterized as a GHRH-receptor agonist. Ipamorelin is a synthetic pentapeptide characterized as a selective agonist at the growth-hormone secretagogue receptor, GHS-R1a.
full CJC-1295 / Ipamorelin profile →IGF-1 LR3
Recombinant IGF-1 analog polypeptide
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 carrying an arginine substitution at position 3 and a 13-residue N-terminal extension. Those two modifications are what define it: they substantially reduce its affinity for the insulin-like growth factor binding proteins (IGFBPs) that sequester native IGF-1 in culture systems.
full IGF-1 LR3 profile →where the research differs
Both compounds are supplied strictly for laboratory research use only. Reported research contexts for each:
CJC-1295 / Ipamorelin
- Dual-pathway GHRH-receptor and GHS-R1a signaling research
- Receptor cross-talk and signal-transduction research models
- Comparative agonist research versus single-component preparations
- Endocrine-signaling research in cellular and pre-clinical models
- Peptide stability and analog structure–activity research
IGF-1 LR3
- IGF-1 receptor binding and signal-transduction research
- PI3K/Akt and MAPK pathway research in cellular models
- Cell-culture media supplementation for proliferation research
- IGFBP interaction and free-ligand availability studies
- Comparative analog research against native IGF-1
shop either compound
Any 2 different compounds take 20% off, any 3 take 30% — applied automatically in the cart, no code. Orders placed Monday–Friday ship by 2pm CT, free over $100.
build a stack with both →frequently asked
What is CJC-1295 / Ipamorelin?
It is a co-formulated research blend of CJC-1295 without DAC (also called Mod GRF 1-29), a GHRH analog, and ipamorelin, a selective GHS-R1a agonist. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
What is the difference between CJC-1295 with and without DAC?
The DAC (drug affinity complex) modification is a chemical addition studied for its effect on the analog's circulating half-life in pre-clinical models. The no-DAC form, Mod GRF 1-29, lacks that modification and is the component used in this blend.
What is IGF-1 LR3?
IGF-1 LR3 is Long R3 insulin-like growth factor 1, a recombinant analog of human IGF-1 with an arginine substitution at position 3 and an N-terminal extension. Verve supplies it as a research compound for laboratory use only, not for human or veterinary use.
How does IGF-1 LR3 differ from native IGF-1?
Its structural modifications reduce affinity for IGF binding proteins, so more of the ligand remains unbound in culture systems. Researchers use that property to control free-ligand availability in in-vitro models.
related comparisons
verve products are sold for laboratory research and development purposes only and are not intended for human or veterinary use of any kind. statements on this site have not been evaluated by the FDA.